We have to thank Horace Wells every time when we sit in the dentist’s chair before some bigger surgery that needs anesthesia. Horace Wells, American dentist (1815 – 1848) is credited for the beginning of application of anesthesia in dentistry. He was a very playful man inclined to experiments. Once, as a volunteer, he was present at the performance of a traveling circus where nitrous oxide, well known as laughing gas, was used. He was impressed with the effects of laughing gas and he realized that it could be applied in dental surgeries. The rest is history. In Europe, laughing gas is not used as anesthesia during the dental surgeries, but other types of dental anesthesia have their roots in his beginnings.